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Transpulmonary Gradient Formula:
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Transpulmonary Gradient (TPG) is the difference between mean pulmonary artery pressure (mPAP) and pulmonary artery wedge pressure (PAWP). It helps assess pulmonary hypertension and differentiate between pre-capillary and post-capillary causes.
The calculator uses the Transpulmonary Gradient formula:
Where:
Explanation: TPG represents the pressure gradient across the pulmonary vascular bed and helps evaluate pulmonary vascular resistance.
Details: TPG is crucial for diagnosing and classifying pulmonary hypertension. A TPG > 12 mmHg suggests pre-capillary pulmonary hypertension, while TPG ≤ 12 mmHg indicates post-capillary pulmonary hypertension.
Tips: Enter mPAP and PAWP values in mmHg. Both values should be positive numbers obtained from right heart catheterization measurements.
Q1: What is the clinical significance of TPG?
A: TPG helps differentiate between pulmonary arterial hypertension (pre-capillary) and pulmonary venous hypertension (post-capillary), guiding appropriate treatment strategies.
Q2: What are normal TPG values?
A: Normal TPG is typically less than 12 mmHg. Values above 12 mmHg indicate elevated pulmonary vascular resistance.
Q3: How is TPG measured clinically?
A: TPG is calculated during right heart catheterization by measuring mPAP and PAWP simultaneously.
Q4: What's the difference between TPG and PVR?
A: TPG is a pressure gradient, while Pulmonary Vascular Resistance (PVR) is calculated as TPG/cardiac output and provides a more comprehensive assessment of pulmonary vascular function.
Q5: When should TPG be used in clinical practice?
A: TPG should be used in the evaluation of pulmonary hypertension, particularly when determining the need for vasodilator therapy and assessing treatment response.