1. What Is Absorption?

Absorption refers to the process by which a substance enters the body's circulation system. In pharmacology and toxicology, it represents the fraction of an administered dose that reaches systemic circulation intact.

2. How Does The Calculator Work?

The calculator uses the absorption formula:

Where:

• \( Absorbed\ Dose \) — Amount of substance that enters systemic circulation (mg)
• \( Administered\ Dose \) — Total amount of substance given (mg)

Explanation: This calculation provides both the fractional absorption (0 to 1) and the percentage absorption (0% to 100%) of the administered dose.

3. Importance Of Absorption Calculation

Details: Accurate absorption calculation is crucial for determining drug bioavailability, optimizing dosage regimens, assessing therapeutic efficacy, and evaluating safety profiles of pharmaceutical compounds.

4. Using The Calculator

Tips: Enter absorbed dose and administered dose in milligrams (mg). Both values must be positive numbers greater than zero. The calculator will provide both fractional and percentage absorption results.

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between absorption and bioavailability?
A: Absorption refers to the process of a substance entering circulation, while bioavailability includes both absorption and first-pass metabolism effects.

Q2: What are typical absorption values for drugs?
A: Absorption varies widely - from near 0% for poorly absorbed drugs to over 90% for well-absorbed compounds. Most oral drugs have absorption between 30-80%.

Q3: How is absorbed dose measured?
A: Typically measured through blood concentration analysis, urinary excretion studies, or specialized imaging techniques in clinical trials.

Q4: What factors affect absorption?
A: Factors include route of administration, drug formulation, gastrointestinal function, food interactions, and individual metabolic differences.

Q5: Can absorption exceed 100%?
A: No, absorption cannot exceed 100% as it represents the fraction of administered dose that enters circulation. Values over 100% indicate measurement error.