Calculator Creatinine Clearance Mdrd

MDRD Equation:

\[ eGFR = 175 \times (SCr)^{-1.154} \times Age^{-0.203} \times 0.742 \text{ (female)} \times 1.212 \text{ (Black)} \]

Serum Creatinine (SCr):

mg/dL

Age:

years

Gender:

Race:

Estimated GFR (eGFR):

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1. What is the MDRD Equation?

The MDRD (Modification of Diet in Renal Disease) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, sex, and race. It was developed to provide a more accurate assessment of kidney function in patients with chronic kidney disease.

2. How Does the Calculator Work?

The calculator uses the MDRD equation:

\[ eGFR = 175 \times (SCr)^{-1.154} \times Age^{-0.203} \times 0.742 \text{ (female)} \times 1.212 \text{ (Black)} \]

Where:

\( SCr \) — Serum creatinine (mg/dL)
\( Age \) — Age in years
0.742 — Female multiplier
1.212 — Black race multiplier

Explanation: The equation uses serum creatinine, age, gender, and race factors to estimate glomerular filtration rate, which reflects kidney function.

3. Importance of eGFR Calculation

Details: Accurate GFR estimation is essential for diagnosing and staging chronic kidney disease, monitoring disease progression, and adjusting medication dosages based on renal function.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, select gender and race. All values must be valid (creatinine > 0, age between 1-120 years).

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between MDRD and CKD-EPI equations?
A: MDRD is more accurate in patients with established CKD, while CKD-EPI performs better at higher GFR levels and is less likely to over-diagnose CKD in healthy individuals.

Q2: What are the limitations of the MDRD equation?
A: Less accurate in elderly patients, extremes of body size, pregnant women, and populations with normal or near-normal kidney function.

Q3: When was the MDRD equation developed?
A: The MDRD equation was developed in 1999 and has been widely used for estimating GFR in clinical practice.

Q4: Is the MDRD equation validated for all populations?
A: While widely used, the equation may require validation or adjustment for specific ethnic groups or populations not represented in the original study.

Q5: Can MDRD be used for drug dosing?
A: For precise drug dosing, especially with narrow therapeutic windows, measured GFR or more specific equations may be preferred in certain clinical situations.