Calculator Creatinine Clearance 24 Hour Urine

Creatinine Clearance Formula:

\[ CrCl = \frac{(U_{cr} \times 24h\ Urine\ Volume)}{(P_{cr} \times 1440)} \]

Creatinine Clearance (CrCl):

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1. What is Creatinine Clearance?

Creatinine clearance is a measure of the glomerular filtration rate (GFR) calculated from a 24-hour urine collection and a blood sample. It estimates how well the kidneys are filtering creatinine from the blood.

2. How Does the Calculator Work?

The calculator uses the creatinine clearance formula:

\[ CrCl = \frac{(U_{cr} \times 24h\ Urine\ Volume)}{(P_{cr} \times 1440)} \]

Where:

\( U_{cr} \) — Urine creatinine concentration (mg/dL)
\( 24h\ Urine\ Volume \) — Total urine volume collected over 24 hours (mL)
\( P_{cr} \) — Plasma creatinine concentration (mg/dL)
\( 1440 \) — Minutes in 24 hours (min/day)

Explanation: This formula calculates the volume of plasma cleared of creatinine per minute, providing an estimate of kidney function.

3. Importance of Creatinine Clearance

Details: Creatinine clearance is important for assessing kidney function, diagnosing renal impairment, monitoring kidney disease progression, and adjusting medication dosages for drugs excreted by the kidneys.

4. Using the Calculator

Tips: Enter urine creatinine in mg/dL, 24-hour urine volume in mL, and plasma creatinine in mg/dL. All values must be positive numbers. Ensure accurate 24-hour urine collection for reliable results.

5. Frequently Asked Questions (FAQ)

Q1: Why is 24-hour urine collection necessary?
A: 24-hour collection provides a complete picture of daily creatinine excretion, accounting for diurnal variations and ensuring accurate clearance calculation.

Q2: What are normal creatinine clearance values?
A: Normal values are approximately 95-125 mL/min for men and 85-115 mL/min for women, but vary with age, muscle mass, and body size.

Q3: How to properly collect 24-hour urine?
A: Discard first morning urine, then collect all urine for next 24 hours including next morning's first void. Keep collection container refrigerated.

Q4: What factors affect creatinine clearance?
A: Age, gender, muscle mass, diet, exercise, medications, and kidney function can all influence creatinine clearance values.

Q5: When is creatinine clearance preferred over eGFR?
A: In patients with extremes of age or muscle mass, amputees, or when precise drug dosing is required for nephrotoxic medications.